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Laparoscopic cholecystectomy is the standard and the most commonly used procedure for the treatment of benign gall bladder diseases, and the subtotal laparoscopic cholecystectomies is one of the rescu…

Laparoscopic cholecystectomy is the standard and the most commonly used procedure for the treatment of benign gall bladder diseases, and the subtotal laparoscopic cholecystectomies is one of the rescue techniques to bailout from and finish safely the difficult cholecystectomies. However, this modality is reported to be associated with more incidence of post-operative bile leak which necessitates further management. Here we present a case of subtotal laparoscopic cholecystectomy which was followed by high output bile leakage for more than 10 days and fortunately sealed spontaneously.

Laktoza intolerantligi (LI) — bu organizmda laktaza fermenti sintezining pasayishi yoki umuman yo'qligi natijasida sut qandi (laktoza) metabolizmining buzilishi bilan kechuvchi holatdir. Jahon s…

Laktoza intolerantligi (LI) — bu organizmda laktaza fermenti sintezining pasayishi yoki umuman yo'qligi natijasida sut qandi (laktoza) metabolizmining buzilishi bilan kechuvchi holatdir. Jahon sog'liqni saqlash tashkiloti (JSST) ma'lumotlariga ko'ra, dunyo aholisining qariyb 65-70 foizi o'smirlik va yetuklik davrida laktozani o'zlashtirish qobiliyatining turli darajadagi pasayishini boshdan kechiradi. Ovqat hazm qilish traktining dispeptik buzilishlari bilan namoyon bo'ladigan ushbu patologiya insonlarning hayot sifatiga, shuningdek, kalsiy va D vitamini kabi muhim mikronutriyentlarning o'zlashtirilishiga bevosita salbiy ta'sir ko'rsatadi. Shu sababli, kasallikning genetik mexanizmlarini o'rganish va unga qarshi to'g'ri dietologik strategiyalarni ishlab chiqish zamonaviy tibbiyot va nutrisiologiyaning dolzarb masalalaridan biri hisoblanadi.

 Ushbu maqolada “muqovamat (qarshilik) adabiyoti”  tushunchasining mohiyati va o‘ziga xos xususiyatlari atrofida fikr yuritiladi. Tadqiqotda atamaning kelib chiqishi, falas…

 Ushbu maqolada “muqovamat (qarshilik) adabiyoti”  tushunchasining mohiyati va o‘ziga xos xususiyatlari atrofida fikr yuritiladi. Tadqiqotda atamaning kelib chiqishi, falastinlik yozuvchi G‘asson Kanafoniy hamda misrlik adabiyotshunos olim G‘oli Shukri qarashlari asosida muqovamat adabiyotining paydo bo‘lish shart-sharoitlari, g‘oyaviy-badiiy mezonlari (insoniylik, milliylik va ijtimoiy o‘lchovlar) tahlil qilingan.

Terahertz (THz)-based antennas are essential for future 6G sensing and short- range communications, especially when multi-band flexibility and compact di- mensions are required. This paper presents a …

Terahertz (THz)-based antennas are essential for future 6G sensing and short- range communications, especially when multi-band flexibility and compact di- mensions are required. This paper presents a compact microstrip patch an- tenna designed for THz applications with tri-band operation. The antenna is formed out of a rectangular patch filled with slots, a defective ground structure (DGS), and a microstrip feedline. Slot loading and the DGS generate various current paths, exciting several resonant modes and enhancing impedance match- ing across the resonant frequency range. The proposed design is implemented on a 30 µm thick RO3003 substrate with a relative permittivity of 3 and loss tan- gent of 0.001. The antenna has physical dimensions of 0.27×0.28×0.03 mm3. Simulation results show the antenna operates at three frequencies with a remark- ably low return loss of up to -61.35 dB over the range of 1.59-3.2 THz. It offers tri-band gains of 6.01, 7.30, and 7.31 dBi, with a voltage standing wave ratio (VSWR) close to the ideal value of 1 for most bands. Furthermore, field distri- butions and power breakdown calculations are performed to better understand the radiation mechanisms and efficiency characteristics at THz frequencies. The antenna radiated power across the band, achieving up to 86.5% of the power accepted. These results indicate that the suggested design provides tri-band ca- pabilities while being a simple, compact and efficient candidate for the demand for improved antennas in next-generation wireless communication systems.

Centralized identity and access management (IDAM) systems suffer from single points of failure, lack of authorization transparency, and susceptibility to in-sider threats and privilege abuse. While ro…

Centralized identity and access management (IDAM) systems suffer from single points of failure, lack of authorization transparency, and susceptibility to in-sider threats and privilege abuse. While role-based access control (RBAC) offers structured permission management, its enforcement through centralized policy engines introduces auditability gaps unacceptable in modern distributed service delivery environments. This paper presents BDLock, a blockchain-enabled two-tier privacy-aware federated IDAM platform integrating OAuth 2.0, OpenID Connect (OIDC), and Hyperledger Fabric 2.4. The first tier validates JSON Web Tokens (JWT) issued by Keycloak against a Spring Boot resource server, the second tier enforces immutable scope-based RBAC rights on the Hyperledger Fabric ledger, ensuring every access decision is tamper-proof and auditable. Unlike prior approaches, BDLock uniquely bridges OAuth-authenticated off-chain identities to cryptographic on-chain Fabric wallet identities, satisfying all six STRIDE-modelled threats categories across both Web2 and Web3 identity models. Validated with up to 1,800 concurrent users, BDLock achieves a peak throughput of approximately 200 transactions per second using round- robin load balancing. At high concurrency, it outperforms single-peer fallback by up to 25%. Furthermore, it maintains uninterrupted access control during peer failures, eliminating the single point of failure found in all nine compared state-of-the-art systems.

Рациональное применение лекарственных средств является важной частью современной системы здравоохранения. Правильный выбор препарата, его дозы, режима и продолжительности применения позволяет повысить…

Рациональное применение лекарственных средств является важной частью современной системы здравоохранения. Правильный выбор препарата, его дозы, режима и продолжительности применения позволяет повысить эффективность лечения и снизить риск возникновения нежелательных реакций. В данной статье рассматривается роль фармацевта в обеспечении рационального использования лекарственных средств.

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact…

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact of type III interferons (IFN-λ) on intestinal recovery, we performed a single-cell RNA sequencing (scRNA-seq) on murine IECs following irradiation. Mice deficient for the IFN-λ receptor in IECs and wild-type mice underwent targeted irradiation. 96h after irradiation, IECs were isolated by fluorescence-activated cell sorting (FACS) based on the expression of EPCAM and analyzed using scRNA-seq. What this record isThis is the entry point for the processed single-cell RNA-seq data of this study. It holds only the documentation: the manifest of every archive and the instructions below. The data itself lives in the 13 records listed below.The 13 data recordsCore analysis outputs — start hereRecordArchiveSizeDOIWT — corecore_WT.tar36.1 GB10.5281/zenodo.22944746KO — corecore_KO.tar36.8 GB10.5281/zenodo.22944748Merged (all cells) — corecore_MergeAllCells.tar42.5 GB10.5281/zenodo.22944750Merged — corecore_Merge01.tar14.0 GB10.5281/zenodo.22944752R session images — optionalRecordArchiveSizeDOIWT — session imagesrdata_WT.tar40.4 GB10.5281/zenodo.22944754WT — session images, enterocytesrdata_WT_05b_Enterocytes.tar25.7 GB10.5281/zenodo.22944756KO — session imagesrdata_KO.tar28.6 GB10.5281/zenodo.22944758Merged (all cells) — session imagesrdata_MergeAllCells.tar31.6 GB10.5281/zenodo.22944760Merged — session imagesrdata_Merge01.tar6.8 GB10.5281/zenodo.22944762Cell Ranger alignments — optionalRecordArchiveSizeDOIWT — BAM, position-sortedbam_WT_possorted.tar33.1 GB10.5281/zenodo.22944764WT — BAM, cell-sortedbam_WT_cellsorted.tar32.1 GB10.5281/zenodo.22944766KO — BAM, position-sortedbam_KO_possorted.tar38.7 GB10.5281/zenodo.22944768KO — BAM, cell-sortedbam_KO_cellsorted.tar36.9 GB10.5281/zenodo.22944770How the collection is organisedFour datasets, each with up to three levels of detail:core — Seurat objects, rendered reports, references and containers. Self-contained: enough to reconstruct and read the whole analysis.rdata — R session images for the clustering resolutions consumed downstream. Optional.bam — Cell Ranger alignments. Optional, and fully regenerable from the raw FASTQ files deposited in GEO.How to use themEvery archive stores paths relative to the same root, 002_IFNL_Recovery_scRNAseq/. Download what you need and extract everything into one empty directory:tar xf *.tarEach file lands in its correct place. The core records alone give a complete but lightweight tree; the others fill it in without overwriting anything.Related resourcesRaw reads: GEO GSE246333 and GSE247149Analysis code: CIML-bioinformatic/ABlab_IFNLGutRestitutionBulk RNA-seq dataset: 10.57745/MB71AU

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact…

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact of type III interferons (IFN-λ) on intestinal recovery, we performed a single-cell RNA sequencing (scRNA-seq) on murine IECs following irradiation. Mice deficient for the IFN-λ receptor in IECs and wild-type mice underwent targeted irradiation. 96h after irradiation, IECs were isolated by fluorescence-activated cell sorting (FACS) based on the expression of EPCAM and analyzed using scRNA-seq. This recordSingle archive bam_KO_cellsorted.tar, 1 file, 36.9 GB.Read alignment produced by Cell Ranger, with its .bai index where applicable. Fully regenerable from the raw FASTQ files (GEO) using the published pipeline; provided for convenience only.How to use these recordsEvery archive stores paths relative to the same root, 002_IFNL_Recovery_scRNAseq/. Download the archives you need and extract them all into one empty directory:tar xf *.tarEach file lands in its correct place in the project tree. Taking only the core records gives a complete but lightweight tree; adding rdata or bam records fills it in without overwriting anything.

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact…

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact of type III interferons (IFN-λ) on intestinal recovery, we performed a single-cell RNA sequencing (scRNA-seq) on murine IECs following irradiation. Mice deficient for the IFN-λ receptor in IECs and wild-type mice underwent targeted irradiation. 96h after irradiation, IECs were isolated by fluorescence-activated cell sorting (FACS) based on the expression of EPCAM and analyzed using scRNA-seq. This recordSingle archive bam_KO_possorted.tar, 2 files, 38.7 GB.Read alignment produced by Cell Ranger, with its .bai index where applicable. Fully regenerable from the raw FASTQ files (GEO) using the published pipeline; provided for convenience only.How to use these recordsEvery archive stores paths relative to the same root, 002_IFNL_Recovery_scRNAseq/. Download the archives you need and extract them all into one empty directory:tar xf *.tarEach file lands in its correct place in the project tree. Taking only the core records gives a complete but lightweight tree; adding rdata or bam records fills it in without overwriting anything.

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact…

Type III interferons induce pyroptosis in gut epithelial cells and impair mucosal repair To investigate the transcriptional program within the intestinal epithelial cells (IECs) controlling the impact of type III interferons (IFN-λ) on intestinal recovery, we performed a single-cell RNA sequencing (scRNA-seq) on murine IECs following irradiation. Mice deficient for the IFN-λ receptor in IECs and wild-type mice underwent targeted irradiation. 96h after irradiation, IECs were isolated by fluorescence-activated cell sorting (FACS) based on the expression of EPCAM and analyzed using scRNA-seq. This recordSingle archive bam_WT_cellsorted.tar, 1 file, 32.1 GB.Read alignment produced by Cell Ranger, with its .bai index where applicable. Fully regenerable from the raw FASTQ files (GEO) using the published pipeline; provided for convenience only.How to use these recordsEvery archive stores paths relative to the same root, 002_IFNL_Recovery_scRNAseq/. Download the archives you need and extract them all into one empty directory:tar xf *.tarEach file lands in its correct place in the project tree. Taking only the core records gives a complete but lightweight tree; adding rdata or bam records fills it in without overwriting anything.