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Maqolada sovet sogʻliqni saqlash tizimi mintaqada shakllana boshlagan 1920-yillar oxiri – 1930-yillar boshidagi Surxondaryo hududining epidemiologik va tibbiy holati arxiv hujjatlari asosida yor…

Maqolada sovet sogʻliqni saqlash tizimi mintaqada shakllana boshlagan 1920-yillar oxiri – 1930-yillar boshidagi Surxondaryo hududining epidemiologik va tibbiy holati arxiv hujjatlari asosida yoritiladi. Bezgakning klassik endemik xususiyati, boshqa keng tarqalgan kasalliklar, okrug ambulatoriyalarining 1927-yildagi hisobotlari, demografik koʻrsatkichlar, tibbiy muassasalar va kadrlar darajasi hamda an'anaviy davolash amaliyoti birgalikda koʻrib chiqiladi. Boshlangʻich holatning oʻta ogʻirligi va yozma statistikaning yetishmasligi keyingi yutuqlarni baholashda hisobga olinishi lozim boʻlgan mezon sifatida asoslanadi.

The study analyzes the impact of technological heritage on public health in an old industrial region using the Vladimir region as a case study. The research relevance is determined by the lack of comp…

The study analyzes the impact of technological heritage on public health in an old industrial region using the Vladimir region as a case study. The research relevance is determined by the lack of comprehensive scientific approaches to assessing accumulated damage in old industrial regions; insufficient understanding of the relationship between environmental pollution and public health at the local level; the need for systematic environmental management and the absence of effective mechanisms for controlling and rehabilitating old industrial territories. The study found that an old industrial region represents a specific anthropotechnogenic ecosystem where past pollution ("ecological memory") combined with modern technological loads creates cumulative health risks for the population. The environmental analysis of this type of region demonstrates serious ecological problems. Particular attention is drawn to the issue of toxic substance accumulation in soils, which creates long-term health risks for the population. The obtained results form the basis for developing regional sustainable development programs that combine environmental safety with socio-economic priorities of old industrial regions.

Cet article présente l’expérience d’une pratique agricole dite « cultures de contre saison » autour de la mare de Dan Doutchi. Longtemps perçue comme une a…

Cet article présente l’expérience d’une pratique agricole dite « cultures de contre saison » autour de la mare de Dan Doutchi. Longtemps perçue comme une activité secondaire, la culture maraîchère est aujourd’hui un palliatif au déficit de production vivrière devenue chronique au Niger. Elle se positionne dans la lignée des pratiques résilientes des populations, mais aussi un levier de développement en milieu rural nigérien. L’objectif de l’étude est d’analyser les enjeux liés à l’exploitation de la mare de Dan Doutchi à travers la culture de contre saison et mieux cerner les contraintes auxquelles elle fait face ainsi que les opportunités qu’elle offre aux populations. L’approche méthodologique s’appuie sur des données quantitatives et qualitatives au prisme des enquêtes socioéconomiques couplées aux entretiens multi catégoriels des acteurs et les observations sur le terrain. Les résultats montrent que la mare de Dan Doutchi dispose d’un potentiel irrigable de 1775 ha partagés entre huit villages riverains dont 741 ha sont exploités par 468 exploitants. Les cultures maraichères autour de la mare s’affirment plus que jamais comme une activité majeure permettant de combler les déficits de la culture sous pluie mais aussi de se procurer de revenus économiques. En effet, 20 % des produits rentrent directement dans la consommation familiale et 80 % sont destinés à la vente. Le revenu engrangé de la commercialisation oscille entre 1 000 000 FCFA à 300.000 FCFA selon les catégories des producteurs. Ces recettes sont injectées dans divers besoins dont 50 % dans l’achat du vivre. En outre, des menaces multiples pèsent sur la mare et l’activité autour dont l’inadaptation de certaines spéculations au milieu physique, le faible niveau financier et technique des producteurs, des pratiques non conservatoires. Face à ces préoccupations, les producteurs s’orientent vers une culture maraîchère résiliente, privilégiant les cultures pour l’autoconsommation, non exigeantes et moins couteuses.

This record contains the reproducibility package for the article “Auditing Reliability after Representation Learning: Decodable Domain Information and Misaligned OOD Scores.” It includes t…

This record contains the reproducibility package for the article “Auditing Reliability after Representation Learning: Decodable Domain Information and Misaligned OOD Scores.” It includes the complete 15-checkpoint v3 result matrix (five seeds × three orthogonality levels), per-image Mahalanobis distances, feature norms, labels and assigned classes, raw scorer arrays, validation reports, derived result tables, and CPU analysis scripts. The raw scorer arrays were rebuilt from cached embeddings and matching classifier heads and checked against the aggregate AUROC and FPR95 results. All 120 run–scorer pairs match within a maximum absolute difference of \(10^{-6}\) for AUROC and \(1.2 \times 10^{-16}\) for FPR95. The descriptive baseline includes six available scorer arrays; it does not report Energy and ViM scores. The scripts reproduce statistical analyses conditional on the supplied scores and checkpoint summaries. The package does not include original model weights, cached embeddings, training logs, or patient/lesion identifiers; therefore, this record cannot be independently audited for training provenance or patient-grouped inference. Analysis scripts require Python 3.10 or later, NumPy, pandas, SciPy, and scikit-learn. See the README for execution instructions.

In 2024, Cascais launched its Urban ReLeaf pilot under the theme “A future-proof urban park – Thermal comfort perceptions on urban greenspaces in Cascais”. The pilot aimed to better …

In 2024, Cascais launched its Urban ReLeaf pilot under the theme “A future-proof urban park – Thermal comfort perceptions on urban greenspaces in Cascais”. The pilot aimed to better understand how citizens perceive bioclimatic comfort in different urban parks and how this information can support local strategies for climate resilience and adaptation. The campaign successfully mobilised 1,500 citizens across four seasonal campaigns: spring (287), summer (552), autumn (229) and winter (432). Participants represented a broad demographic profile, with 60% women, 18% young people under 24, and 13% older adults above 65. Citizens were engaged through onsite signage, QR-code surveys, seasonal kickoff events, and outreach via schools, community associations, and Cascais Jovem. Vulnerable groups, including elderly residents and young people, were specifically targeted to ensure inclusiveness. Preliminary findings revealed notable contrasts across Cascais’ greenspaces. Quinta da Carreira Urban Park was consistently rated as the most comfortable environment, while Abóboda Urban Park and Bosque das Fontainhas presented the poorest conditions during summer, particularly regarding temperature, sun exposure, wind, and humidity. These results provide clear evidence for identifying “comfort hotspots” for citizens during heat events, as well as “discomfort hotspots” requiring targeted intervention in planning and investment. Beyond data collection, the pilot had tangible policy impacts. Results were directly used to inform the Green Spaces and Tree Protection Regulation and contributed to the good practice manual Renatura. Citizens expressed appreciation for having their perceptions considered in municipal decision-making, confirming the value of participatory citizen science approaches. The 2025 campaigns expanded on these achievements by combining perception data with objective environmental monitoring. TRH sensors (temperature and humidity) will be deployed across selected parks to generate complementary datasets, creating a robust evidence base for municipal planning. Seasonal campaigns will continue, supported by cultural and community activities to broaden participation, and youth recruitment will be reinforced through Cascais Jovem. Overall, the Cascais pilot demonstrates how citizen-powered data can inform local climate adaptation strategies, strengthen community resilience, and ensure that urban greening policies respond to both scientific evidence and lived experiences. The integration of these approaches into municipal frameworks illustrates the transformative potential of Urban ReLeaf for building inclusive, future-proof urban environments.

  Abstract William Shakespeare’s Macbeth (c. 1606) stands as one of the most intellectually rigorous and psychologically harrowing explorations of sovereign usurpation, moral degeneration, …

  Abstract William Shakespeare’s Macbeth (c. 1606) stands as one of the most intellectually rigorous and psychologically harrowing explorations of sovereign usurpation, moral degeneration, and the tragic sublime in the Elizabethan-Jacobean dramatic canon. Written during the early years of the Jacobean era a period saturated with anxieties regarding legitimate succession, regicide, divine right, and the looming shadow of the Gunpowder Plot the tragedy examines the catastrophic implosion of an honorable warrior when exposed to the corrosive alchemy of unbridled ambition and supernatural incitement. This paper explores the psychological, political, and metaphysical dimensions of Macbeth’s descent into tyranny, analyzing how externalized prophecies materialize as internal psychic fractures that dismantle both the individual ego and the body politic. By examining the structural breakdown of Scottish feudal order, the subversion of gender performativity through Lady Macbeth and the Weird Sisters, the linguistic contagion of equivocation, and the ultimate restoration of normative sovereignty under Malcolm, this study argues that Shakespeare posits moral conscience as an inescapable tribunal from which no tyrant can successfully secede. Furthermore, the drama illustrates how macro-level political violence reverberates through micro-level domestic ruin, turning the Scottish crown into a crown of thorns and converting a heroic defender of the realm into an isolated, nihilistic butcher trapped within the circular prison of his own atrocities. Through meticulous textual attention to metonymy, spatial claustrophobia, somnambulism, and atmospheric irony, Shakespeare crafts an enduring literary monument to the perils of sovereign hubris, demonstrating how imaginative drama serves as a vital philosophical repository for investigating the darkest recesses of the human soul. Within the broader framework of early modern intellectual history, this study situates the play not merely as a localized theatrical response to contemporary Stuart politics, but as a universalized, ontological inquiry into the fragility of the human ethical constitution when confronted with the bottomless abyss of political temptation. Keywords: Macbeth, William Shakespeare, Jacobean drama, political tyranny, psychoanalytic criticism, sovereign legitimacy, moral conscience, the tragic sublime 1. Introduction: Jacobean Anxieties and the Tragedy of Usurpation William Shakespeare’s Macbeth occupies an extraordinarily privileged and volatile space in early modern English drama, reflecting the profound political, religious, and philosophical anxieties of the Jacobean transition. Ascending the English throne in 1603 following the Elizabethan era, King James VI of Scotland brought with him an intense personal and intellectual obsession with divine right kingship, dynastic legitimacy, demonology, and the absolute horror of regicide preoccupations intensified by harrowing historical trauma such as the Gowrie Conspiracy and the 1605 Gunpowder Plot. Shakespeare, acutely attuned to the shifting political topography of his patron’s court, crafted a lean, concentrated tragedy that directly engages these contemporary preoccupations while universalizing them into an existential meditation on the anatomy of evil. Unlike the expansive geographical sweeps of Antony and Cleopatra or the sprawling familial fractures of King Lear, Macbeth operates as a pressure cooker of moral conscience, compressing time, space, and psychic torment into an inexorable downward spiral that mirrors the rapid unraveling of a compromised soul. The play opens not in a court of stable governance, but amidst the desolate, lightning-scarred heaths of Scotland, where the natural and moral orders are immediately inverted by the cryptic incantations of the Weird Sisters. In this liminal frontier, Macbeth hitherto celebrated as the valiant savior of Duncan’s crown encounters forces that externalize his own latent, repressed ambitions. This paper examines in comprehensive detail how Shakespeare deploys atmospheric setting, relentless iambic propulsion, shifting linguistic registers, and profound psychological interiority to critique the mechanics of tyranny and to affirm the ultimate resilience of moral law. In doing so, Shakespeare interrogates the philosophical underpinnings of power, demonstrating that when a sovereign ruptures the sacred contract binding ruler, subject, and cosmos, the entire body politic is plunged into a state of unnatural inversion. By shifting the lens from the battlefield of physical combat to the blood-drenched chambers of the human conscience, Shakespeare exposes how abstract political treason materializes as visceral, somatic terror at the individual level, transforming the domestic interior and the royal hall into spaces of paranoia, ghosts, and irreversible moral collapse. 2. The Weird Sisters and the Contagion of Equivocation The metaphysical machinery of Macbeth is set into motion by the Weird Sisters, figures who resist tidy categorization within Elizabethan demonology. They are neither wholly classical Fates nor traditional Christian witches, but ambiguous, liminal entities who embody the chaotic, unsettling undercurrents of a universe indifferent to human morality. Their famous utterance "Fair is foul, and foul is fair" (I.i.11) establishes the thematic and linguistic template of the entire drama, signaling an ontological inversion where distinctions between virtue and villainy, truth and deception, are systematically dissolved. When the witches intercept Macbeth and Banquo on the heath, their prophecies do not mechanically compel Macbeth to murder; rather, they act as a catalyst that awakens dormant, unspeakable desires. The prompt integration of prophecy into private thought reveals that the seeds of treason are already sown within Macbeth’s psyche. However, the linguistic medium through which the witches operate equivocation serves as the primary weapon of psychological subversion. The equivocations of the witches ("None of women born / Shall harm Macbeth," IV.i.80-81) exploit human hubris, relying on literal interpretations to mask catastrophic realities. This culture of linguistic instability permeates the entire Scottish court, where language ceases to be an instrument of communication and becomes a mask for treachery, culminating in a world where words lose their anchoring tether to objective truth. 3. The Anatomy of Ambition: Macbeth’s Internal Partition Macbeth’s character arc represents one of the most sophisticated studies of moral degeneration in world literature. Initially introduced as "brave Macbeth" (I.ii.16) who "unseam'd him from the nave to the chaps" (I.ii.22) in defense of the realm, his violence is initially sanctioned and valorized by the state. However, the transition from sanctioned martial violence to illicit political assassination exposes the profound instability of his ego. Before the murder of Duncan, Macbeth experiences acute psychological hesitation, articulating a comprehensive moral calculus that recognizes the horror of regicide: "He's here in double trust; First, as I am his kinsman and his subject, Strong both against the deed; then, as his host, Who should against his murderer shut the door, Not bear the knife himself." (I.vii.12-16) This soliloquy highlights Macbeth's acute awareness of the social, familial, and divine bonds he is about to shatter. He recognizes that Duncan’s virtues "will plead like angels, trumpet-tongued, against / The deep damnation of his taking-off" (I.vii.19-20). Yet, this moral clarity is repeatedly undermined by his "vaulting ambition" (I.vii.27) and the relentless emotional manipulation of his wife. The murder of Duncan does not fulfill Macbeth; instead, it initiates an infinite regress of paranoia and bloodshed. To secure a throne founded on usurpation, Macbeth must commit serial violence, eliminating Banquo, attempting to destroy Fleance, and ultimately slaughtering Macduff’s entire household. Each crime deepens his psychic isolation, transforming him from a conflicted human being into a mechanized tyrant who views human life as utterly devoid of meaning. 4. Gender, Performativity, and the Subversion of the Maternal The tragedy’s interrogation of gender roles is central to its exploration of violence and ambition. Lady Macbeth’s famous invocation to the "spirits / That tend on mortal thoughts" to "unsex" her and fill her "from the crown to the toe top-full / Of direst cruelty" (I.v.40-43) represents a radical attempt to divorce feminine maternity from political agency. In the Jacobean symbolic economy, the female body was frequently associated with nurture, mercy, and generation; Lady Macbeth deliberately seeks to cauterize these faculties, demanding that her "compunctious visitings of nature / Shake no my fell purpose" (I.v.44-45).                 The tragedy demonstrates, however, that the biological and psychological repression of the maternal cannot be sustained without severe somatic costs. Lady Macbeth’s rejection of nurturing instincts symbolized by her harrowing assertion that she would have dashed the brains out of her nursing infant comes back to haunt her in the form of deep-seated somnambulism. In Act V, her sleepwalking scenes reveal a fractured psyche where the repressed maternal and moral conscience erupt uncontrollably. Her obsessive hand-washing ritual ("Out, damned spot! out, I say!" V.i.30) is the somatic externalization of an unerasable guilt, proving that nature, violently expelled through performative hardness, inevitably reclaims its dominion over the human soul. 5. Kingship Versus Tyranny: The Political Philosophy of the Realm Shakespeare utilizes the stark contrast between Duncan, Macbeth, and the rightful heir Malcolm to articulate a profound early modern political philosophy regarding legitimate sovereignty. Duncan embodies the traditional, patriarchal ideal of sacred kingship, a ruler whose authority is anchored in grace, generosity, and natural harmony. His presence fosters fertility and social cohesion, as noted by Banquo’s observation regarding the martlet’s "temple-haunting martlet" nests around Inverness (I.vi.4-6). In sharp contrast, Macbeth’s tyranny turns Scotland into a desolate wasteland where "each new morn / New widows howl, new orphans cry, new sorrows / Strike heaven on the face" (IV.iii.4-6). Tyranny, in Shakespeare’s formulation, is not merely political oppression; it is a cosmic pathology. Under Macbeth, the natural order is thrown into grotesque reverse: horses eat each other, darkness covers the daytime sky, and owls hunt falcons. The political body reflects the diseased soul of its sovereign. Malcolm’s eventual catalog of royal virtues justice, verity, temp'rance, stableness, bounty, perseverance, mercy, lowliness, devotion, patience, courage, fortitude (IV.iii.92-94) serves as a comprehensive mirror for magistrates, establishing the moral prerequisites for restoring health to the fractured state. 6. The Somatic Manifestation of Guilt: Hallucinations and Sleep One of the most striking psychological dimensions of Macbeth is the physicalization of guilt through hallucinations and sleep deprivation. Sleep, in the drama, is repeatedly identified as the vital balm of human existence "the innocent sleep, / Sleep that knits up the ravell'd sleave of care" (II.ii.35-36). When Macbeth murders Duncan in his sleep, he literally and metaphorically murders sleep itself, condemning himself to chronic insomnia and perpetual psychological torment. The hallucination of the floating dagger ("Is this a dagger which I see before me," II.i.33) and the subsequent apparition of Banquo’s ghost at the royal banquet table function as objective correlatives of Macbeth’s fractured conscience. These supernatural manifestations are internal projections rather than external agents; they represent the unbearable weight of repressed guilt breaking through the defenses of the conscious ego. Banquo’s ghost, sitting ominously in Macbeth’s place at the feast, visually dramatizes the usurper's total lack of legitimate succession and his inability to secure his hard-won throne. Through these harrowing sequences, Shakespeare illustrates that the human mind possesses an autonomous, unrelenting moral register that cannot be silenced by political power or military might. 7. Metonymy, Space, and Atmospheric Claustrophobia The spatial poetics of Macbeth contribute significantly to its overarching sense of psychological entrapment and moral claustrophobia. Unlike plays that utilize open expanses or shifting international locales, Macbeth contracts its spatial domain inward, moving from vast battlefields to fortified castles, narrow chambers, and ultimately to the isolated, besieged stronghold of Dunsinane. This spatial compression is mirrored linguistically through the dense deployment of metonymy, synecdoche, and somber imagery. Blood functions as the dominant metonymic thread of the tragedy, appearing in dozens of variations ranging from the heroic blood of the battlefield to the indelible stains of treason. As Macbeth observes after the murder, "Will all great Neptune’s ocean wash this blood / Clean from my hand? No, this my hand will rather / The multitudinous seas incarnadine, / Making the green one red" (II.ii.57-60). This hyperbole encapsulates the sheer scale of moral contamination, demonstrating how an isolated act of violence expands geometrically to taint the entire macrocosm. 8. The Tragic Sublime and the Nihilistic Void In the final movements of the play, as the military forces of Malcolm and Macduff encircle Dunsinane, Macbeth attains a strange, haunting iteration of the tragic sublime. Stripped of his illusions, abandoned by his disaffected nobles, and informed of the suicide of his wife, Macbeth confronts the terrifying realization of human insignificance. His famous "Tomorrow, and tomorrow, and tomorrow" soliloquy (V.v.17-28) represents the ultimate articulation of existential nihilism in Renaissance drama: "Out, out, brief candle! Life's but a walking shadow, a poor player That struts and frets his hour upon the stage And then is heard no more: it is a tale Told by an idiot, full of sound and fury, Signifying nothing." (V.v.23-28) This profound nihilism is the inevitable destination of a life dedicated entirely to the accumulation of power through ruthless violence. Macbeth has traded his "keepers," his moral community, and his eternal soul for a shadow, discovering too late that absolute power results in absolute desolation. Yet, even within this abyssal despair, Macbeth retains a desperate, tragic courage, refusing to yield entirely to Malcolm's mercy and choosing instead to die fighting with a harness on his back. 9. Restoration, Order, and the Cyclical Nature of Politics The tragedy concludes with the ritualistic decapitation of the tyrant and the restoration of legitimate, linear succession under Malcolm. The staging of Macbeth's severed head upon a pole serves as a visceral reminder of the violent fate awaiting those who subvert the natural and political order. Malcolm’s closing speech looks forward to a period of institutional healing, promising to reward the Thames, recall exiled friends, and realign Scotland with divine grace. However, despite the formal closure provided by the restoration of normative order, the dramatic resonance of Macbeth leaves a lingering, cautionary shadow. The historical cycle of Scottish succession marked by regicides, civil wars, and usurpations implies that political order is perpetually fragile, requiring eternal vigilance against the seductive whispers of ambition and tyranny. The play thus transcends its specific Jacobean historical moment to offer an enduring psychological and political blueprint for understanding the corrupting nature of sovereign power. Conclusion William Shakespeare’s Macbeth remains an inexhaustible masterwork for investigating the dark intersections of ambition, politics, psychology, and morality. By charting Macbeth’s catastrophic descent from noble warrior to isolated tyrant, Shakespeare exposes the profound fragility of human civilization when confronted with unbridled ego and the contagion of equivocation. Yet, the tragedy refuses to succumb to absolute nihilism; through the unyielding witness of human conscience, the haunting somatic eruptions of guilt, and the eventual restoration of political equilibrium, the text asserts that moral law is an inescapable reality of the human condition. Ultimately, Macbeth endures as a supreme literary monument to the perils of sovereign hubris, reminding readers across centuries that the greatest battlefield of all resides within the dark, labyrinthine chambers of the human heart. References Shakespeare, W. (1997). The Riverside Shakespeare (G. Blakemore Evans, Ed.). Houghton Mifflin. (Original work published c. 1606). Greenblatt, S. (2004). Will in the World: How Shakespeare Became Shakespeare. W. W. Norton & Company. Bradley, A. C. (1904). Shakespearean Tragedy: Lectures on Hamlet, Othello, King Lear, Macbeth. Macmillan.Dollimore, J. (1984). Radical Tragedy: Religion, Ideology and Power in the Drama of Shakespeare and His Contemporaries. University of Chicago Press. Kermode, F. (2000). Shakespeare's Language. Farrar, Straus and Giroux.

The activity of antioxidant enzymes of some types of ornamental herbaceous plants has been studied under conditions of controlled soil contamination with cadmium and lead ions in order to identify pla…

The activity of antioxidant enzymes of some types of ornamental herbaceous plants has been studied under conditions of controlled soil contamination with cadmium and lead ions in order to identify plant resistance to polymetallic stress. Increased activity of catalase, peroxidase, and polyphenol oxidase was detected in seedlings of Ageratum houstonianum cv. Bule Lagoon and Agrostemma githago L. both when pollutants were applied separately and when they were applied together to the growing medium.

Reports a DFT study of the SO₃ splitting mechanism on metal oxide catalysts and the development of a materials screening platform. Over 1,000 materials were evaluated thermodynamically under two opera…

Reports a DFT study of the SO₃ splitting mechanism on metal oxide catalysts and the development of a materials screening platform. Over 1,000 materials were evaluated thermodynamically under two operating scenarios, producing a shortlist of 50 candidates benchmarked against V₂O₅ and Fe₂O₃ on reaction energetics and cost. Eight of them were selected for experimental synthesis and testing.

Materials used during the FAIR Clinic: Prepare Software for Publishing, delivered as part of the event FAIR Clinics: From Principles to Practice organised by the UMCG Digital Competence Center (DCC) o…

Materials used during the FAIR Clinic: Prepare Software for Publishing, delivered as part of the event FAIR Clinics: From Principles to Practice organised by the UMCG Digital Competence Center (DCC) on 8 October 2026.   This workshop supports researchers in preparing repository for publishing software to support sharing, publication, reuse, and citation. Participants work through practical activities focused on repository structure, documentation, licensing, software citation, and other elements that support FAIR and reusable software.