Our Work

This report reviews the editorial and bibliometric performance of the Journal of Alzheimer's Disease (JAD) from its founding in 1998 through August 2026. It covers trends from 2020 to 2026 in manuscri…

This report reviews the editorial and bibliometric performance of the Journal of Alzheimer's Disease (JAD) from its founding in 1998 through August 2026. It covers trends from 2020 to 2026 in manuscripts received and accepted, uptake of optional open access, and time from submission to first decision. It also covers the 2025 Journal Impact Factor (3.4) and 5-year Impact Factor, and the distribution of authorship and readership across world regions. The citation analysis includes 40,756 citations to JAD in 2025, the top 20 journals citing JAD, the ten most-cited JAD articles of all time and of 2025, and article viewership from 2022 to 2026, including the rise in readership after the move to the Sage Journals platform. The report also summarizes 2026 special issues, the companion Journal of Alzheimer's Disease Reports, and the 2026 Mark A. Smith Alzheimer Award article on sex differences in tau, astrocytic and neurodegenerative plasma biomarkers.

This zipped archive of a GitHub repository includes the experimental data (csv files) collected for the reduction of N2O to N2 by purified Stutzerimonas stuzeri nitrous oxide reductase (N2OR or NosZ) …

This zipped archive of a GitHub repository includes the experimental data (csv files) collected for the reduction of N2O to N2 by purified Stutzerimonas stuzeri nitrous oxide reductase (N2OR or NosZ) and the R code (qmd files) used to analyze these data. The code used to prepare dual isotope plots (boxplots or isotope maps) is also included. A link to the corresponding GitHub repository is also provided. These data are being made available as part of the submission of a manuscript entitled "Determination of the Kinetic Isotope Effects for Nitrous Oxide Reduction by Purified Form II Nitrous Oxide Reductase" to Biogeosciences. Manuscript authors: Louisa R. Ellis, James J. Moran, Eric L. Hegg*, and Elise D. Rivett*.

Precision Mito was started by two people living with mitochondrial disease and seeking answers. That personal experience shapes our commitment to taking patient questions seriously, making complex evi…

Precision Mito was started by two people living with mitochondrial disease and seeking answers. That personal experience shapes our commitment to taking patient questions seriously, making complex evidence easier to understand, and supporting more informed conversations with clinicians and researchers. These debate papers come from that search for clarity. When findings appear to conflict, we want to understand what each study shows, how differences in methods or context may explain the disagreement, and what evidence could resolve it. We lay out the arguments for both sides and invite the authors to correct our interpretation and talk with one another, so uncertainty can lead to better questions and clearer answers. Our goal is clearer understanding for people living with mitochondrial disease, their families, and the clinicians and researchers working to help them. We welcome explanations that reconcile both papers as well as evidence that challenges either interpretation. Our lived experience motivates the questions; scientific conclusions must rest on evidence. Study [1] reports: "CoQ10 supplementation does not reduce muscle pain in patients with statin myalgia.". Study [2] reports: "Also, the symptoms of SAM significantly improved in the active group (p < 0.001): the intensity of muscle pain decreased from 6.7 ± 1.72 to 3.2 ± 2.1 (p < 0.01, -53.4 ± 28.2%)". The existing review identifies unresolved evidence. Differences in study conditions need clarification; a direct experimental contradiction is not established. Focused synthesis of two primary studies and separately cited review context identifying an unresolved question. Different interpretations and study contexts do not establish a direct experimental contradiction. This is not a new systematic review, meta-analysis, experimental study or determination that either paper is correct. Private author responses and contacts are excluded.

 This paper examines how the strategic management of foreign economic activity influences enterprise competitiveness through market diversification, resource allocation, productivity improvement,…

 This paper examines how the strategic management of foreign economic activity influences enterprise competitiveness through market diversification, resource allocation, productivity improvement, innovation, international network development, and risk management. The study synthesizes classical strategic-management concepts with international-business theory and recent evidence from the World Trade Organization, OECD, UN Trade and Development, and the World Bank. The central argument is that foreign economic activity creates competitive advantage only when international expansion is treated as an integrated strategic process rather than as a set of isolated export transactions. A structured management cycle is proposed that links environmental analysis, market and entry-mode selection, capability development, implementation, monitoring, and organizational learning. Particular attention is paid to digitalization, global value-chain participation, supply-chain resilience, foreign-exchange exposure, compliance, and the use of performance indicators. The paper concludes that systematic strategic management strengthens the capacity of enterprises to convert international opportunities into durable advantages in cost, quality, innovation, speed, brand reputation, and market access.

O envelhecimento cutâneo é um processo natural, porém fatores extrínsecos podem acelerá-lo, reduzindo a produção de proteínas estruturais da pele…

O envelhecimento cutâneo é um processo natural, porém fatores extrínsecos podem acelerá-lo, reduzindo a produção de proteínas estruturais da pele, como colágeno e elastina, resultando em flacidez e rugas. Com o aumento da expectativa de vida, cresceu também a demanda por procedimentos estéticos menos invasivos. Diante disso, este estudo tem como objetivo realizar uma revisão crítica da literatura científica sobre a eficácia do ultrassom microfocado (HIFU) no rejuvenescimento facial, abordando mecanismos de ação, protocolos de aplicação, resultados clínicos, segurança, indicações e contraindicações. A pesquisa foi conduzida entre março e maio de 2025, com a seleção de artigos e estudos publicados de 2020 a 2025, em português e inglês, obtidos por meio de bases como Google Acadêmico, Scielo, PubMed, Zenodo e repositórios institucionais. Para contextualização, abordam-se inicialmente a estrutura e fisiologia da pele, destacando as camadas alvo da ação do HIFU. Em seguida, discute-se envelhecimento cutâneo, considerando os fatores extrínsecos e intrínsecos que comprometem a sustentação e elasticidade da pele. A metodologia adotada permitiu identificar lacunas nos estudos existentes, como a ausência de protocolos padronizados e a escassez de pesquisas longitudinais que avaliem os efeitos em longo prazo. Os achados demonstram que o HIFU é uma alternativa promissora e segura para o rejuvenescimento facial, com benefícios visíveis e menor tempo de recuperação.

The MD simulation input files, one representative trajectory from each conducting mechanism, eigenvector analysis, and the in-house data-processing and data plotting codes are uploaded to Zenodo:

Supplementary material associated with paper titled  Integrative interactome analysis for mechanistic discovery and drug repurposing in rare diseases: GPX4-related rare skeletal dysplasia accepte…

Supplementary material associated with paper titled  Integrative interactome analysis for mechanistic discovery and drug repurposing in rare diseases: GPX4-related rare skeletal dysplasia accepted for publication in Proceedings of 2027 Pacific Symposium on Biocomputing. 

Version 3 removes the ungulate multimodel Inference analyses from the dataset and adds kmz data for the site locations of the subplots analyzed in portions of the analyses.

O artigo investiga as ações de Responsabilidade Social Corporativa (RSC) interna e externa da Usina Sucroenergática de Santa Fé, de Nova Europa (SP), por meio de seus …

O artigo investiga as ações de Responsabilidade Social Corporativa (RSC) interna e externa da Usina Sucroenergática de Santa Fé, de Nova Europa (SP), por meio de seus Relatórios de Sustentabilidade (2022-2025) à luz das normas da Global Reporting Initiative (GRI). Destaca-se que a RSC consolidou-se como pilar estratégico para sua longevidade, exigindo equilíbrio entre produtividade econômica, preservação ambiental e desenvolvimento humano. Caracterizada como qualitativa, descritiva e documental, a pesquisa utilizou a Análise de Conteúdo de Bardin, criando três categorias de analíticas: (a) Práticas Trabalhistas e Desenvolvimento Humano, (b) Engajamento e Desenvolvimento Comunitário, e (c) Ética, Governança Social e Direitos Humanos. Revelou-se que, internamente, há investimentos expressivos em treinamento, benefícios assistenciais, programas de saúde e segurança e diversidade na alta governança. Externamente, destacam-se o Instituto Itaquerê, doações de etanol e o plantio de mudas nativas. Quanto à ética e governança, há repúdio ao trabalho infantil e à escravidão. Assim, apresentou-se três inferências críticas: o investimento como instrumento de gestão e peça de legitimação institucional; ações externas são estratégicas e alinhadas ao ESG e geração de valor compartilhado; a governança e a conformidade com normas internacionais sugere credibilidade perante investidores e mercado. Desta forma, a Usina Santa Fé constrói uma narrativa de maturidade em RSC interna e externa, porém a pesquisa reconhece a limitação do viés de autorrelato e sugere que estudos futuros.