Our Work

In the recent years, some linguistic advances occurred in the field of cognitive linguistics. Cognitive linguistics is the interpretation of thoughts, concepts, mental phenomena occurring in human con…

In the recent years, some linguistic advances occurred in the field of cognitive linguistics. Cognitive linguistics is the interpretation of thoughts, concepts, mental phenomena occurring in human conscious and in nature. Besides, oil and gas engineering context requires us understanding figurative terminology in that field. However, it is difficult to comprehend the idea of concepts in the technical context if one has no mental image of that field. Therefore, cognitive-frame model reveals representation of complex knowledge structure of oil and gas industry and its terminological system at the conceptual level and encoded in language. 

Introduction: inborn errors of immunity (IEI) are predominantly monogenic disorders presenting with infections, autoimmunity, autoinflammation, allergy, and malignancy. Over the last 25 years, the Int…

Introduction: inborn errors of immunity (IEI) are predominantly monogenic disorders presenting with infections, autoimmunity, autoinflammation, allergy, and malignancy. Over the last 25 years, the International Union of Immunological Societies (IUIS) Expert Committee has published 14 classification reports, tracking the field's evolution. Objective: to synthesize the conceptual and quantitative evolution of IEI as documented in IUIS classification reports from 1999 to 2024. Method: scoping review following Arksey & O'Malley's framework. We systematically searched PubMed for IUIS reports (1999–2024). Data extracted included number of recognized disorders, genetic defects, classification structure, and clinical manifestations. Clinical phenotypes were categorized as infectious, autoimmune, autoinflammatory, allergic, malignant, or non-immunological. Results: recognized IEI increased eightfold from 59 disorders in 1999 to 559 in 2024, arising from 508 genes plus 17 phenocopies. Three growth phases were identified: linear (1999–2005), accelerated (2005–2015), and exponential with structural consolidation (2015–2024). Major paradigm shifts included: creation of immune dysregulation and autoinflammatory tables (2005), nomenclature change to "inborn errors of immunity" (2017), and introduction of somatic mutation phenocopies (2014). In 2024, 43% of newly described IEI fall into autoinflammatory or immune dysregulation categories. Non-immunological manifestations are present in 100% of syndromic IEI and bone marrow failure syndromes. Conclusions: the evolution of IEI classification reflects a fundamental reconceptualization of immune dysfunction, from infection-focused deficiencies to multi-system dysregulation disorders. This framework supports pathway-based diagnosis and precision therapy, with implications for rheumatology, hematology, allergy, and neurology.

Future large telecommunication platforms, cargo tugs, and exploration stages will require very high power electric propulsion, making it essential for Europe to consolidate sovereign capability in the…

Future large telecommunication platforms, cargo tugs, and exploration stages will require very high power electric propulsion, making it essential for Europe to consolidate sovereign capability in the 10-25 kW Hall class. This paper reports the development and testing of two CHEOPS-VHP-BB building blocks on the 20 kW dual-channel TANDEM thruster: an upgraded high-current hollow cathode and additively manufactured anode distributors. The work combines the University of Pisa's design capabilities with Aerospazio's testing expertise, large vacuum facilities, and advanced diagnostics. The anodes were designed for additive manufacturing with the aid of free-molecular-flow modelling, produced by laser powder bed fusion in stainless steel, assessed for azimuthal uniformity with custom Aerospazio instrumentation, and full-scale fired on TANDEM in Xe, Kr, and Ar. The cathode was designed using thermo-mechanical simulations, fabricated in three identical models, and characterised through thermal, ignition, and diode-mode sweeps from 10 to 100 A on all three propellants. One unit completed full performance characterisation, while a 1,000 h argon endurance run and environmental tests (TVAC, shock, vibration) are ongoing. The other units were integrated and tested on TANDEM and are scheduled for tests with Safran's PPS ® 20k. Results demonstrate the first publicly reported 3D-printed anode installed and fired on a 20 kW-class Hall thruster, achieving azimuthal uniformity within ∼10%. The cathode operated stably across all propellants with low discharge voltage and RMS current oscillations, and has been successfully demonstrated on TANDEM. These results enhance Aerospazio's test capabilities and validate UniPi's design approach, supporting a credible path to TRL 6 for rapid European adoption of very high power electric propulsion.

Annotatsiya. Tezisda o’zbek tilida ta’lim oluvchi boshlang’ich sinf o’quvchilarining ingliz tilida yo’l qo’yadigan tipik grammatik xatolari ko’rib chiqiladi. …

Annotatsiya. Tezisda o’zbek tilida ta’lim oluvchi boshlang’ich sinf o’quvchilarining ingliz tilida yo’l qo’yadigan tipik grammatik xatolari ko’rib chiqiladi. Har bir xato uchun uning o’zbek tilidagi manbai ko’rsatiladi. Kuzatuvlar muallifning o’zi dars beradigan sinflarda olib borilgan.

El sarcoma de Kaposi es una neoplasia vascular multifocal asociada al herpesvirus humano tipo 8, cuya forma epidémica afecta principalmente a pacientes con inmunosupresión avanzada por V…

El sarcoma de Kaposi es una neoplasia vascular multifocal asociada al herpesvirus humano tipo 8, cuya forma epidémica afecta principalmente a pacientes con inmunosupresión avanzada por VIH. Se presenta el caso de un varón de 27 años con sida, en quien el estudio necrópsico reveló una extensa afectación visceral por sarcoma de Kaposi, con compromiso prácticamente continuo del tracto gastrointestinal y sin lesiones cutáneas clínicamente evidentes. Durante la evaluación clínica, las adenopatías inguinales motivaron inicialmente la sospecha de linfoma no Hodgkin. La punción aspirativa con aguja fina sugirió sarcoma de Kaposi, diagnóstico posteriormente sustentado por el estudio histopatológico de la exéresis ganglionar. La evolución fue desfavorable, con progresión a fallo multiorgánico. La necropsia permitió establecer la verdadera magnitud de la diseminación tumoral y evidenció una marcada discordancia entre la extensión anatómica de la enfermedad y su expresión clínica.

This replication package presents the data available at the research paper submitted to ACM International Conference on Foundations of Software Engineering 2027.

Africa's vast natural wealth stands in stark contrast to its enduring poverty and economic stagnation – a contradiction rooted in colonial legacies that established extractive institutions and externa…

Africa's vast natural wealth stands in stark contrast to its enduring poverty and economic stagnation – a contradiction rooted in colonial legacies that established extractive institutions and external dependencies. Today, the continent remains heavily reliant on raw material exports, with intra-African trade accounting for just 13.8% of total trade. This over-dependence has stifled diversification and reinforced structural vulnerabilities. This essay examines the historical and systemic factors that have shaped Africa's economic trajectory, arguing that sustainable transformation requires industrialization, financial inclusion, and regional integration. It introduces three innovative economic models: skill-backed lending to expand financial access through competencies rather than collateral; apprenticeship-for-ownership programs to promote equity and transfer of productive assets; and the One-Continent, One-Supply Chain policy to build an integrated African production network. By investing in bold policy reforms, strategic regional cooperation, and community-driven enterprises, Africa can start a path toward economic autonomy and inclusive, long-term growth.